DISPRIN – IS IT SAFE? USES, SIDE-EFFECTS, DOSAGE
WHAT IS DISPRIN?
Disprin is an antipyretic and analgesic medicine mainly used for the treatment of fever and pain relief. It is also used to prevent the blood clots in blood vessels by suppressing the normal functioning of the platelets. This is also used to treat diseases like Pericarditis, Kawasaki Disease, and Reye’s Syndrome. It is an anti-inflammatory and nonsteroidal drug(NSAID) available in many countries worldwide. The manufacturer of this medicine is Reckitt Benckiser(India) Ltd.
DISPRIN – IS IT SAFE? USES, SIDE-EFFECTS, DOSAGE
What is the Generic name(s)?
What is its composition?
How does it work?
What are its uses?
How effective is this medicine?
Is it addictive?
What is the dosage?
HOW TO TAKE THIS?
WHAT IF I MISS A DOSE?
WHAT TO DO IN CASE OF OVERDOSAGE?
WHAT TO DO IF THERE IS AN ALLERGIC REACTION?
CAN I DRIVE AFTER TAKING IT?
CAN IT BE TAKEN WITH FOOD?
CAN IT BE TAKEN ON AN EMPTY STOMACH?
CAN IT BE TAKEN WITH ALCOHOL?
WHAT ARE THE SIDE-EFFECTS?
DOES THIS MEDICINE HAS ANY DRUG INTERACTIONS?
PRECAUTIONS
IS IT SAFE TO USE IF I AM PREGNANT?
IS IT SAFE TO USE IF I AM BREASTFEEDING?
CAN THIS MEDICINE BE GIVEN TO CHILDREN AND INFANTS?
IS THIS MEDICINE AVAILABLE AS OVER THE COUNTER(OTC) PRODUCT?
FREQUENTLY ASKED QUESTIONS
Reference
WHAT IS THE GENERIC NAME(S)
The generic name of Disprin is Aspirin. It comes in form of dispersible tablets.
The Active Ingredient in this medicine is Acetylsalicylic Acid or Aspirin ph Eur.
WHAT IS ITS COMPOSITION?
This medicine is a composition of Acetylsalicylic Acid – 3o0 mg
- 50 mg of Calcium carbonate, Maize Starch, Citric Acid Anhydrous, Sodium Lauryl Sulphate, Saccharin, Crospovidone, and Lime flavour.
HOW DOES IT WORK?
There is an enzyme known as COX(cyclooxygenase) which is responsible for the production of Prostaglandins which cause swelling, inflammation, and pain in your body. It also clumps the platelets together and makes blood clots.
- The presence of Acetylsalicylic Acid in this medicine blocks the action of COX and works as a painkiller by preventing the production of these chemicals.
- This medicine contains 300 mg of Aspirin as an active ingredient to remit the fever.
- It also works as a blood-thinner and increases the chances of surviving a heart failure. It stops the clotting of blood which can block the sufficient blood supply to the heart.
- The presence of Aspirin as an active ingredient in this medicine works as an anti-inflammatory painkiller which blocks the release of chemicals which cause pain.
WHAT ARE ITS USES?
Disprin is used for the treatment of the diseases like:
PAIN AND FEVER
This medicine used to relieve pains of:
- A headache
- A migraine
- Neuralgia or nerve pain
- A sore throat
- A toothache
- Menstrual pain
- Bone metastasis
It is also used for the treatment of pain, fever, and aches caused by Flu, influenza, and Cold.
INFLAMMATION
It is used for the treatment of inflammation caused by:
- Sciatica
- Strains
- Sprains
- Fibrositis
- Muscular ache
- A backache
- Lumbago
RHEUMATIC FEVER
- It treats the fever caused by Rheumatism whether it may be a low or high fever.
- It also treats the mild to severe pain and inflammation caused by Rheumatoid Arthritis which is called as Rheumatoid fever.
ARTHRITIS
- This medicine used in the treatment of Arthritis and the associated symptoms like pain, swelling, and joint stiffness.
- It also treats the fever and swelling of joints caused due to Arthritis and osteoarthritis.
ACUTE CORONARY SYNDROME
- The acute coronary syndrome is a health condition which blocks the supplying of blood to the heart muscles. Disprin is used to treat such health conditions.
- It is used in the improvement of survival of a heart attack in emergency situations.
- This medicine also used as a prevention of the after complications of a heart bypass surgery in some cases.
KAWASAKI DISEASE
- It is used in the treatment of Kawasaki disease or the mucocutaneous Lymph Node Syndrome found in children.
- It helps to reduce the symptoms associated with the Kawasaki disease.
It is strictly recommended not to use this medicine for the above-mentioned diseases without the consultation or reference of your doctor.
HOW EFFECTIVE IS THIS MEDICINE?
- As an analgesic, Disprin is very effective for acute pain in your body.
- The effectiveness of this medicine starts to work within 30 minutes of intake.
- The effectiveness of this medicine lasts up to 6 hours.
- The overall bioavailability of this medicine is around 70%.
IS IT ADDICTIVE?
No, it is not addictive. This medicine contains no such ingredient which could be habit-forming for you.
WHAT IS THE DOSAGE?
The dosage of this medicine varies for children to adults.
FOR ADULTS
The basic dose for adults is 300-600 mg, every 3-4 hours. But it differs disease to disease.
- PAIN & FEVER
The recommended dose for pain and any type of fever in adults is 325-650 mg every 4 hours.
The maximum recommended dose per day is 3900 mg
- MINI STROKE
The recommended dose for mini-stroke is 75-160 mg once a day.
- HEART ATTACK
The recommended dose for heart attack is 150-450 mg as soon as there is a symptom of heart attack is seen.
The recommended dose for the prevention of a heart attack is 75-160 mg once daily.
- PREVENTION OF COMPLICATIONS AFTER A HEART BYPASS SURGERY
The recommended dose for the prevention of the after complications of a heart bypass surgery is 75-160 mg once daily.
FOR CHILDREN
In children, Disprin is used for diseases like Rheumatic fever, Juvenile Chronic Arthritis, and Kawasaki disease. The dosage for each disease is also different.
- RHEUMATIC FEVER & JUVENILE CHRONIC ARTHRITIS
The initial dose for these two diseases is 15-20 mg/kg every 6 hours. The maintenance dose of this medicine is 20 mg/kg every 4-6 hours.
- KAWASAKI DISEASE
For Kawasaki disease, the initial dose is 10 mg/kg every 8 hours until the remission of the fever. The maintenance dose is 3-5 mg/kg once a day.
CAUTION FOR THE DOSAGE FOR BOTH THE ADULTS AND CHILDREN
It is a strict warning not to self-medicate this medicine without consulting or approval of a doctor. Don’t self-medicate with this medicine without consulting a doctor.
HOW TO TAKE THIS?
- Take a glass of water and dissolve the tablet completely.
- Drink this solution immediately without delay.
- Don’t break or chew this medicine unless doing so is as per the advice of your doctor.
WHAT IF I MISS A DOSE?
- In case of a missed dose take the medicine immediately as you remember it.
- If it is already near the next dose then skip the missed one.
- If you are missing the doses regularly it is best to set an alarm for your safety and convenience.
It is recommended to consult your doctor to set the next schedule of dosages in such cases.
WHAT TO DO IN CASE OF OVERDOSAGE?
The overdose of this medicine may be acute or chronic. The mortality rate of an acute case is 2% whereas in chronic cases it is lethal and 25%.
The poisonous effect of an overdose of this medicine may cause adverse effects like:
- Chronic gastritis
- Blood vomiting
- Severe drowsiness
- Vertigo
- Warm extremities with bounding pulses
- Sweating
- Deafness
- Coma
- Hyperventilation
- An increased respiratory rate
In such conditions, consult your doctor immediately or rush for emergency medical care if the symptoms persist.
There are some uncommon effects of an overdose of this medicine which may occur:
- Haematemesis
- Hypoglycaemia
- Hyperpyrexia
- Increased INR/PTR
- Hypokalaemia
- Intravascular Coagulation
- Thrombocytopaenia
- Renal failure
- Non-cardiac pulmonary oedema
Warning: An overdose of this medicine could be fatal for children.
WHAT TO DO IF THERE IS AN ALLERGIC REACTION?
As we have mentioned earlier you may go through some allergic reactions after taking of this medicine. You may experience severe itchy rashes, angioedema, bronchospasm or asthma attack.
In any of the above allergic reactions, you must stop the medicine immediately. If the reactions persist for more than 4-5 hours you must rush for immediate medical care.
CAN I DRIVE AFTER TAKING IT?
In a number of cases, this medicine causes dizziness and drowsiness after intake. Sometimes, it causes blurred vision which is very dangerous while driving.
It also impairs your thinking ability for some time temporarily.
Hence, it is recommended not to drive and not to do heavy machinery-related works after taking Disprin.
CAN IT BE TAKEN WITH FOOD?
Yes, it is recommended to take this medicine with food to avoid all the stomach and intestinal disorders.
CAN IT BE TAKEN ON AN EMPTY STOMACH?
No, never take this medicine on an empty stomach. It may cause severe gastritis and other intestinal disorders which may be dangerous for you.
CAN IT BE TAKEN WITH ALCOHOL?
No, don’t take this medicine with alcohol. Rather it is recommended not to take alcohol during the entire time of medication.
Taking it with alcohol causes severe adverse effects like prolonged abdominal bleeding which causes black and tarry stool.
WHAT ARE THE SIDE-EFFECTS?
The side-effects of this medicine are not the same for all. But in some cases, it may cause the following side-effects:
GASTROINTESTINAL
- Stomach pain
- Heartburn
- Black or tarry Bloodstained stools
- Blood Vomiting
- Nausea
- Indigestion
- Severe Gastritis
- Intestinal bleeding
- Diarrhoea
- Abdominal distress
- Constipation
- Acid or Sour Stomach
- Gastrointestinal haemorrhage
- Oesophageal ulceration
MISCELLANEOUS
- A headache
- Drowsiness
- Hearing Problems like the sensation of ringing in your ears
- Allergic reactions
- Dizziness
- Ototoxicity
- Dyspepsia
- Pruritis
- Rash
- Blurred vision
- Confusion
- Hallucination
- Seizure
- Rapid breathing
- Yellow coloured skin and eyes
- Irritation
DOES THIS MEDICINE HAS ANY DRUG INTERACTIONS?
Yes, Disprin has interactions with some specific drugs which can reduce its efficacy, such as:
-
ANTICOAGULANT MEDICINES
- Phenindione
- Warfarin
- Rivaroxaban
- Dabigatran
- Heparin
- Apixaban
- Enoxaparin
-
ANTIPLATELET OR BLOOD-THINNING MEDICINES
- Prasugrel
- Clopidogrel
- Coumadin
-
NSAIDS
- Naproxen
- Ibuprofen
- Diclofenac
- Indometacin
- Hifenac MR
-
CORTICOSTEROIDS
- Dexamethasone
- Prednisolone
-
SSRI ANTIDEPRESSANTS
- Paroxetine
- Fluoxetine
- Citalopram
-
LOOP DIURETICS
- Bumetanide
- Furosemide
- Spironolactone
-
SOME OTHER MEDICINES
- Aspirin
- Venlafaxine
- Zoledronic Acid
- Methotrexate
- Acetazolamide
- Probenecid
- Sulfinpyrazone
- Vitamin C
- Anadin original
- Micropirin
- Beechams powder
- Nu-seals Aspirin
- Antacids
- Activated Charcoal
- Urinary Alkalizers
- Nitroglycerine
- Tetracycline
- Beta-adrenergic
- Exogenous Insulin
- Sulfonylureas Insulin
- Kaopectate
- Nimesulide
PRECAUTIONS
You have to take certain precautions while taking Dispirin. You must inform your doctor about the past and current health conditions before taking this medicine.
Inform your doctor if you are taking other medications for some other diseases. Avoid the intake of this medicine if you have a history or currently suffering from:
- Peptic ulcer or stomach ulcer
- Hypersensitivity
- Kidney impairment
- Liver impairment
- Blood disorder
- Renal impairment
- Hepatic impairment
- History of heartburn
- Anaemia
- Stomach Ulcer
- Haemophilia
- Allergic reactions to other painkillers or other NSAIDs
- Rhinitis or nasal inflammation
- Angioedema or swelling of throat, lips, and tongue
- Itchy rash
- An Asthma attack
- Gout
- Heart failure
- Hypoprothrombinemia
- G6PD or Glucose-6-phosphate dehydrogenase
- Dehydration
- On Anticoagulant therapy
- Diabetes
- Cardiovascular diseases
Do not give this medicine to children under 16 years of age without the advice of a doctor.
Keep this medicine out of the reach of children and pets.
Avoid exposure to sunlight after taking this medicine.
Don’t take this medicine if you are taking steroids for any other disease.
IS IT SAFE TO USE IF I AM PREGNANT?
It is strictly prohibited to take Disprin when you are in the third trimester of pregnancy. It can cause:
- A delayed and prolonged labour.
- Risk of bleeding during delivery in both the mother and the infant.
- Excess harmful effects on your baby.
- Intracranial haemorrhage which can cause loss of the baby.
- A low birth weight baby.
In other stages of pregnancy, you must consult your Gynaecologist before taking this medicine. Self-medication could be dangerous for both of you and your baby.
IS IT SAFE TO USE IF I AM BREASTFEEDING?
No, never take this medicine during breastfeeding. There are records of a significant amount of this medicine passing into the baby through breast milk.
- It could be fatal for the infant.
- It may weaken the platelet function in your baby.
- There is a risk of the increased Reye’s Syndrome in infants.
- It may produce Hypoprothrombinemia.
Hence, it is recommended to consult your doctor before taking of Disprin if you are breastfeeding.
CAN THIS MEDICINE BE GIVEN TO CHILDREN AND INFANTS?
This medicine is not at all recommended for infants. Or else it may develop Reye’s Syndrome in them.
It can be given to children over 16 years of age but under the supervision of a doctor.
In some cases, a lower dose of Disprin is given to children to treat diseases like Kawasaki and Reye’s Syndrome under the supervision of a doctor.
It is not recommended for the children who are recovering from chickenpox or flu-like symptoms. Always consult with the doctor before giving it to a child.
IS THIS MEDICINE AVAILABLE AS OVER THE COUNTER(OTC) PRODUCT?
Disprin is taken in the combination with other antiplatelet medicines as an OTC to treat the bleeding disorder in patients under the supervision of a doctor.
In the case of a heart attack, it is given with the medicine Sorbitrate as an OTC also under the supervision of a doctor.
It is strictly recommended to never self-medicate this medicine as an over the counter product without consulting a doctor.
FREQUENTLY ASKED QUESTIONS
- Can this medicine be given to older people?
Ans – This medicine is not recommended for older people because it may rupture the lining of the gastrointestinal tract and cause intestinal bleeding in them.
- What to do in case of an expired dose of this medicine?
Ans – Taking of an expired dose of this medicine is ineffective for the disease and can cause adverse effects in your body. In such cases, consult your doctor for further advice and for the further dosage.
- Can I take this in heavy menstrual bleeding?
Ans – Though this medicine is recommended to treat the menstrual pain but avoid to take it when you are going through heavy menstrual bleeding.
- Can I take Aspirin instead of Disprin for a headache?
Ans – Though Disprin contains Aspirin as an active ingredient it is recommended to take the particular medicine as per the advice of your doctor.
- Is it safe to take this medicine for a long time?
Ans – A prolonged usage of this medicine may or may not cause any adverse effects. But in some cases, it causes an allergic reaction and gastrointestinal bleeding. It is recommended to consult your doctor if you are taking it for a long time.
- Is Disprin safe for the patients have high blood pressure?
Ans – This medicine works effectively against coronary diseases. It is recommended to add this as an OTC for blood pressure after proper consultation with your doctor only. Don’t self-medicate this medicine for any disease.
Reference
Wikipedia page on Nonsteroidal anti-inflammatory drug
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