Navidoxine – Is it safe? Uses, Side effects, Dosage

What is Navidoxine?

Navidoxine is an Antiemetic drug and it is a piperazine derivative.

• It is a primary medication to treat nausea or other conditions occurs due to the motion sickness.
• Navodoxine is also used in the treatment of complications in pregnancy.
• This medicine is normally available in many countries throughout the world.

Navidoxine – Is it safe? Uses, Side effects, Dosage

What is the Generic name(s)?
What is its composition?
How does Navidoxine work?
What are its uses?
How effective is this medicine?
Is it addictive?
What is the dosage?
What if I miss a dose?
What to do in case of overdosage?
What to do if there is an allergic reaction?
What are the Side Effects?
Does this medicine has any drug interactions?
Can Navidoxine be taken with food?
Can Navidoxine be taken with alcohol?
Can Navidoxine be taken on an empty stomach?
Precautions
Is it safe to use if I am pregnant?
Is it safe to use if I am breastfeeding?
Can Navidoxine be given to Children and Infants?
Is Navidoxine available as Over The Counter (OTC) product?
Frequently Asked Questions
Reference

What is the Generic name(s)?

The two Generic name(s) of this drug Navidoxine are Meclizine and Pyridoxine (which is also known as Vitamin B6).

What is its composition?

Navidoxine is made up of two main active ingredients. They are

• Meclozine dihydrochloride (a derivative of Mecl0ozine)- 25mg
• Vitamin B6 -50 mg, which is also referred to as Pyridoxine Hydrochloride (a derivative of Pyridoxine)
• Sometimes, another active ingredient Mebeverine hydrochloride (a derivative of Mebeverine) is also used to produce this drug.

How does Navidoxine work?

Navidoxine acts as a coenzyme for the metabolism of biomolecules such as Carbohydrates, Proteins and Fats (It has the properties of coenzyme because of the presence of active ingredient Pyridoxine in it). It then works by lowering the level of Histamine, a chemical substance in the body.

What are its uses?

This Navidoxine is mainly used in the purpose of prevention, control and the treatment of certain medical conditions and diseases. Such conditions are listed below,

• Nausea caused by Motion sickness
• Vomiting caused by motion sickness
• Dizziness caused by motion sickness
• Drowsiness caused by motion sickness
• Inadequate intake of dietary substances
• Deficiency caused by drug inducing process
• Pregnancy complications
• Problems in Mental stability
• Vertigo (caused due to the inner ear infection or defect)
• Anaemic condition
• Convulsions
• Disturbances in Neurological system and in its functions
• Homocystinuria

How effective is this medicine?

This medicine is quite fast in showing its effectiveness on the conditions. The observations had reported that the effect is shown on the same day or the next day. Its shows its effectiveness to treat the condition is between 24 hours to 36 hours.

Is it addictive?

No, this drug is not addictive. This medicine does not have the capacity to be addictive or habit forming. There is no evidence reported to prove that this drug causes addiction.

What is the dosage?

The dosage can vary depends upon the following conditions,

• Type and severity of the condition
• The weight of the person
• Age of the person
• The health condition of the patient
• Allergies of the patient

However, this drug is usually used by pregnant women unless it is absolutely necessary. The dosage of this drug should not exceed 50 mg per day and too with short and regular interval of time.

What if I miss a dose?

•  The drug won’t show a potential effect if you miss the dose at some time.        
• A specific amount of drug must be present in your body at all times. 
• Consume the missed dose as soon as you remember it if it’s not already time for the second dose as if it is not advisable not to take the double dosage.

What to do in case of overdosage?

• If you have taken an overdose, it is advisable to contact your consulting physician immediately.
• The overdosage of this Drug would eventually result in poisonous or serious side effects.
• The high dosage may result in Central Nervous System stimulation or depression (due to the presence of meclizine dihydrochloride). The other symptoms observed are,
• Fixed and dilated pupils
• Flushed face
• Dry mouth
• Depression with drowsiness
• Coma and excitement
• Extended level of mood changes
• Seizures and tonic-clonic seizures
• Arrhythmias
• Hypotension or Hypertension
• Hallucinations
• Ataxia and tremors
• Affect psychological behaviour
• Hyperthermia and tachycardia

What to do if there is an allergic reaction?

Hypersensitivity to this tablet is a contraindication. Try to avoid the drug if you have:

• Hypersensitivity
• Sensitivity

The allergic reactions caused due to this drug are rare and are considered as unusual symptoms. Consult the doctor if you experience any of the following allergic conditions:

• Skin Rashes
• Irritation
• Troubled breathing
• Swelling in body parts (particularly in face, eyes and lips)

What are the Side Effects?

Side effects may cause due to the ingredients present in the drug. These are rarely observed symptoms but can be serious health issues. Some positive side effects which occur due to the consumption of this drug are as follows,

• Neuropathy
• Restlessness
• Discomfort in the abdominal region
• Ataxia
• Blurriness in vision
• Drowsiness
• Dry mouth
• Constipation
• Numbness in feet
• Retention in urine excretion
• Paraesthesia
• Perioral numbness
• Sensory neuropathy
• Unstable gait
• Somnolence
• Fatigue
• Decreased level of folic acid in serum
• Headache
• Burning or tightness in the chest
• Stomach upset
• Prickling
• Anaphylactoid reaction
• Hallucinations
• Anxiety
• Anorexia
• Tinnitus
• Insomnia
• Psychotic disorder
• Dry mouth
• Dryness in the nasal region
• Diarrhoea
• Palpitations
• Polyuria
• Tachycardia
• Hypotension
• Weakness
• Ataxia
• Tremors
• Increased in weight
• Euphoric mood
• Excitability
• Disorders in movement (such as Parkinson’s diseases)
• Dizziness
• Gain of appetite
• Diplopia
• Peripheral neuropathy

Does this medicine has any drug interactions?

There are certain drugs which are proved to interact with Navidoxine. This drug to drug interactions will result in either retardation of the effect of drugs or cause life-threatening side effects.

The drugs which are observed to interact with this drug are,

• Levodopa
• Medications used for pain
• Vitamin supplements
• Sleeping pills
• Tranquillizers
• Phenobarbital
• Medicines used to treat seizure
• Sedative drugs

Can it be taken with food?

No, it cannot be taken with food. The physician or pharmacist will prefer this medicine to be taken before food to experience the better and efficient result.

Can it be taken with alcohol?

No, this drug cannot be taken with alcohol. It may affect the Central Nervous system (CNS) and may increase the effect of Peripheral neuropathy.

Can it be taken on an empty stomach?

No, it cannot be taken on an empty stomach. The physician or pharmacist will prefer this medicine to be taken before food.

What are the precautions I need to take?

Some of the warnings and precautions you need to take before taking this drug are,

• Inform your doctor if you are taking any other drugs, herbal supplements and vitamin supplements before consuming this drug.
• It is always safe to discuss with the doctor about your allergic reactions towards the active ingredients present in the tablets.
• Consult about your past and present medical conditions (such as pre-existing diseases or the period of pregnancy) with your doctor before taking this medicine.
• Avoid alcoholic beverages or smoking while consuming these tablets.
• Patients suffering from epilepsy and patients with severe renal impairment should use this medicine with caution.
• Avoid using this drug simultaneously with other Central Nervous System (CNS) depressant drugs, or with drugs having anticholinergic properties, or with MAO inhibitors.
• Long-term use of large doses of pyridoxine has been associated with the development of severe peripheral neuropathies.
• Patients who have rare hereditary problems of galactose intolerance or lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Is it safe to use if I am pregnant?

Actually, it is prescribed to use if you are pregnant in the prevention of its symptoms as nausea and vomiting. The presence of an active ingredient in this drug Pyridoxine hydrochloride is safe to consume while pregnant. But the Meclizine dihydrochloride in the drug may cause the serious side effects for mother and foetus by increasing the malformations.

Is it safe to use if I am breastfeeding?

No, it is not safe to use if you are breastfeeding an infant. The ingredients as Pyridoxine hydrochloride and Meclizine dihydrochloride can pass into the breast milk which may affect the infant. So it is safe to consult the doctor about the risks of this drug.

Can this medicine be given to Children and Infants?

No, this medicine cannot be given to Children and Infants. If it is used in children under 12 years (unless it is prescribed by the doctor) it may result in dangerous side effects.

In young children, Central Nervous system stimulation is predominant. Severe toxicity effect in children (and even in adults) may result in cerebral edema, deep coma, respiratory depression, cardiorespiratory collapse, and death.

Is this medicine available as Over The Counter (OTC) product?

Yes, this medicine is available as Over The Counter (OTC) product.

Frequently Asked Questions

How can you store this drug?

These tablets should be stored at the room temperature (which is about 25-degrees Celcius) and away from direct heat, light and moisture. Don’t keep the drug container open for a long time as it may make the medicine lose its efficiency. For the same reasons, don’t keep the drug at a low temperature (freezing temperature) inside the refrigerator (unless it is mentioned in the package). Keep it away from children and pets.

Avoid flushing the expired tablets in toilets or sinks. It is because improper discarding of these tablets may contaminate the environment which can cause injurious conditions to human health.

When to avoid this drug?

Avoid this drug and do tell your doctor if you had experience or experiencing the following diseases or conditions as follows,

• Planning to get pregnant
• Blockage in Urinary tract
• Bladder outflow obstruction
• Glaucoma
• Pyloric stenosis
• Impaired gastric and intestinal mobility
• Myasthenia gravis
• Asthma
• Dementia
• Breastfeeding
• Asthma
• Enlarged prostate
• Glaucoma
• Loading of tissues

Can I drive or operate heavy machinery after taking this drug?

No, you cannot drive or operate heavy machinery after taking this drug. It depends on your condition. This drug may impair the ability to concentrate or react to the situations. If you feel dizziness or drowsiness after taking this drug, avoid driving or operating heavy machinery. People are reported to experience Hypotension, Headache, Lowering of blood pressure after the consumption of this drug.

What is the cost of this drug?

This drug consists of 10 tablets in a box costs about Rs. 100.

 Is there any particular food items to be avoided while taking this drug?

No, there are no particular food items to be avoided while taking this drug unless you are allergic to any food substances.

What happens if I take expired medicine?

This medicine when it is expired loses its efficiency to treat the specific condition. However, some women may face the symptoms of life-threatening conditions such as Heart diseases, seizures and allergic reactions. Hence, consult your physician as soon as possible if you consumed the expired drug.

What is the effect of this on organs?

Navidoxine can cause some serious side effects in the Liver. Liver functions should be monitored by taking blood tests. The evidence is also found to have some side effects in Kidney too. It can be lead to the condition of Urinary Tract Infection (UTI). The symptoms will be observed as,

•   Loss of Appetite
•  Yellowing of skin
• Weakening in strength
• Tiredness
• Dark urination   
• Swelling in body parts

How to take this drug?

It is always safe to consult your doctor to know how to take this drug. It is usually taken orally by mouth. This drug should be taken before food. It can be taken once, twice or thrice per day at a regular interval of time. It can be taken with or without a glass of water. Although the symptoms are not there anymore, you should not stop the medication until you complete the dosage.

Can this drug be used to treat Complications in pregnancy or Nausea and vomiting during pregnancy?

Yes, this drug is used as a common medication in the treatment of preventing nausea and vomiting due to the pregnancy. It is possible by with the presence of the active ingredients (salts). Sometimes, these ingredients also used to treat the complications during pregnancy.

What is the pharmacokinetics of this drug?

This drug is moderately absorbed by the cells or tissues in the body. The drug binds to the protein to the minimum level of about 40%. It is actively metabolized in the liver (hepatic regions). This medicine is excreted by kidney through urine (about 80%). The half-life elimination of this medicine is about half an hour.

Can this drug be stopped abruptly?

No, this drug cannot be stopped abruptly. When you stopped to take this medicine abruptly or immediately, it would result in the rebound effects. Instead, you can decrease the level of this drug’s dosage according to the advice of your doctor.

Reference

Wikipedia page on Motion sickness

 

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