Deriva CMS – Is it safe? Uses, Side Effects, Dosage

What is Deriva CMS?

Deriva CMS belongs to the group (third generation medications) of drugs known as Retinoids.  The manufacturer of this deriva cms gel is Glenmark Pharmaceuticals Ltd.

• This medicine is available in the gel (cream) form.
• It’s a primary medication which is used in the treatment of Acne vulgaris.
• It reduces the blackheads formations in the skin.
• It is responsible for renewing and restoring the texture and tone of the skin in a fast and effective way.
• It is effective in the process of healing pimples and decreases the inflammation and swelling of the skin.

Deriva CMS – Is it safe? Uses, Side Effects, Dosage

What is the Generic name(s)?
What is its composition?
How does Deriva CMS work?
What are its uses?
How effective is this medicine?
Is it addictive?
What is the dosage?
What if I miss a dose?
What to do in case of overdosage?
What to do if there is an allergic reaction?
What are the side effects?
Does this medicine has any drug interactions?
Precautions
Is it safe to use if I am pregnant?
Is it safe to use if I am breastfeeding?
Can this medicine be given to children and infants?
Is this medicine available as an Over The Counter (OTC) product?
Frequently asked questions
Reference

What is the Generic name(s)?

This Deriva CMS gel has two generic active ingredients – Adapalene Microspheres and Clindamycin Phosphate.

What is its composition?

Deriva CMS is composed of two main active ingredients such as

• Adapalene Microspheres – 0.1% W/W
• Clindamycin Phosphate – 1% W/W

How does Deriva CMS work?

Deriva CMS works by decreasing the formation of microcomedones. It would result in treating the conditions such as acne and keratosis pilaris by lowering the counts of papules and pustules in acne.

It works by mechanically combining with some specific retinoic and nuclear receptors along with retinoid X receptors which are used for treating other skin problems. It would result in normalizing the differentiation process of follicular epithelial cells which leads to the lowering of the microcomedone formation. However, it does not combine with cytosolic receptor protein.

What are its uses?

Deriva CMS is mainly used for the purpose of prevention, control and the treatment of certain skin-related conditions and diseases. Such conditions are listed below:

• Acne vulgaris and Mild-moderate acne
• Pimples
• Spots (black spots) on the skin
• Blackheads
• Keratosis pilaris
• Scarring
• Bacterial infections of internal organs
• Papules
• Severe acne on chest
• Skin infections
• Skin breakout and skin breakout Vulgaris
• Serious skin inflammation on confront
• Clogged Pores
• Mellow to direct inflammation in the skin

How effective is this medicine?

The effectiveness of Deriva CMS varies according to the patients and their conditions. This gel has the potency to shows its effect within 2 to 3 days to treat the problems.

Is it addictive?

No, the gel is not proved or observed to have any kind of addiction or habit-forming properties. So this is not addictive.

What is the dosage?

This packaging size of Deriva CMS which is normally prescribed is a 15-gram tube. Only a small amount of this gel is applied on the infected skin. This gel is generally advised to be applied only once or twice in a day to avoid rebound effects of allergic reactions.

The doctor’s decision on the dosage depends upon the following conditions:

• Type and severity of the skin condition
• The weight of the person
• Age and Sex of the person
• The health condition of the patient
• Patients reported allergic conditions
• Patient’s pre-medical history

What if I miss a dose?

•  The drug would lose its capacity to show the efficiency if you miss the dose in a day.
• A little amount of gel must be present in the skin for a certain amount of time.
• Apply the missed dose as soon as you remember it but only if it’s not already time for the next dose (because it may result in double dosage).

What to do in case of overdosage?

If you apply more quantity(overdosage) of Deriva CMS on your skin, wash your skin with plenty of water as soon as possible. It may cause intense irritation in the skin, so consult your doctor immediately.

What to do if there is an allergic reaction?

Some of the reported allergic reactions are

• Dryness in the skin and lips
• Itching of the skin or lips
• Scaling of the skin and lips
• Slight burning sensations in the skin
• Peeling of the skin
• Redness of the skin
• Troubled breathing
• Stinging in the skin
• Irritation around the eyes
• Worsening of acne effect
• Painful skin

These allergic reactions reported as rare and unusual. If you are experiencing any of these symptoms on regular basis, consult your physician immediately.

What are the side effects?

This gel can cause some unwanted side effects which would need immediate medical attention. They are

• Inflammation or irritation in the vaginal area
• Vulvovaginal discomfort or discomfort
• Diarrhoea with mucus and blood
• Inflammation in the bowel
• Erythema
• Cutaneous dryness
• Pruritus

Does this medicine has any drug interactions?

Some drugs are observed to cause a drug to drug interaction while it is combined with deriva cms gel. It may result in losing the efficiency of the drug.

The drugs which can cause dangerous interaction with this gel are:

• Drugs which contains substances such as sulfur, resorcinol, salicylic acid, alpha hydroxy or glycolic acid.
• Erythromycin metronidazole or aminoglycosides
• Vitamin supplements or any herbal supplements
• Alcohol-containing prepared drugs
• Abrasive soaps and cleaners
• Astringents

Precautions

Some of the precautions and warnings which should be followed while taking this drug are:

• Avoid applying in eyes, nose and mouth as it may cause burning, redness and irritation (especially in eyes).
• It should not be applied for abrasions, cuts and sunburned skin.
• Due to its composition of active ingredients, deriva cms gel can cause a burning sensation in the skin if your skin is exposed to sunlight for a long period of time.
• Consult your doctor if you are allergic to any of the ingredients present in the gel.
• Always consult with your doctor regarding your pre-existing diseases and medical history before using this medicine.
• Inform your physician if you are consuming any other drugs or applying any other cream on the skin to avoid drug to drug interactions.
• Consult your doctor if you experience the allergic reactions such as swelling in the skin, lips, tongue or throat.
• Avoid waxing while using this drug.
• If you are applying this medicine, you should not apply makeup or moisturizer on the skin.
• Always inform your doctor if you have adverse effects while consuming Vitamin A medications or Retinoid medications such as Isoretinoid.

Is it safe to use if I am pregnant?

No, it isn’t safe to use if you are pregnant. Recent animal studies observed that this gel can cause harmful effects on the baby. So consult your doctor before using the gel during pregnancy due to its undesirable effect on the foetus.

Is it safe to use if I am breastfeeding?

Yes, it is probably considered safe to use if you are breastfeeding. It is because this gel cannot pass through the breast milk which can affect the infant. However, it is always safe to consult with your doctor beforehand.

Can this medicine be given to children and infants?

No, this medicine shouldn’t be given to children under 12 years and infants. It is always better to consult with your paediatrician before using this gel.

Is this medicine available as an Over The Counter (OTC) product?

Yes, this medicine is available as an Over The Counter (OTC) product.

Frequently asked questions

How to take this drug?

Wash your skin thoroughly with water and dry the skin before applying the cream. Apply the gel according to the instructions of your physician. It can be used once or twice in a day. Apply a small amount of gel in the skin where you get the spots. Avoid disturbing or squeezing the spots while applying the cream to avoid scarring on the skin. It can be used up to a minimum of 2 weeks and a maximum of 12 weeks.

What is the price of this drug?

The cost of  Deriva CMS gel ( a tube of 15 gram) is about Rs. 198.

When to avoid this drug?

It is advisable to avoid this gel if you have any of the following:

• Sensitivity
• Hypersensitivity
• Pregnant
• Planning to get pregnant

How can you store this drug?

This deriva gel is usually stored at the room temperature (which is about 15 to 25- degrees Celcius). Keep it away from direct heat, light and moisture. This gel may lose its potency if it is kept open for a long period of time. Don’t store the drug at a low temperature (freezing temperature) inside the refrigerator (unless it is mentioned on the package). Keep it away from children’s reach and pets to avoid dangerous effects.

Avoid flushing the expired gel in toilets or sinks. If it is discarded in this improper way, it may contaminate the environment.

What are the substitutes for this gel?

Some of the prescribed substitutes for this gel are,

• Accare Gel
• Acnecure gel
• Acnovate gel
• Acneril gel
• Adaferin gel
• Adapen gel
• Adaple Gel
• Adaret (15 gram) gel and Adaret (15 gram) (skin) gel
• Adiff gel
• Adina gel
• Aditop gel and Aditop C gel
• Adlene AD cream
• Alangel cream
• Alene gel
• Apalene gel
• Apgel cream
• Clinmiface A gel
• Cutiwel Gel
• Clindot A gel
• Clincent A gel
• Clindapene cream
• Clearwin plus gel
• Daple gle
• Deriva MS cream
• DEE C Gel
• Edplin gel
• Excex gel
• Femcinol ADP
• Foracne plus gel
• Facelin A gel
• Glintra A gel
• Lacne gel
• Medapine gel
• Nilac A gel
• Rozac  gel
• Soflene gel
• Vandep gel
• Wegamycin A gel

The above-mentioned gels are considered to have the same active ingredients and the potency like Deriva CMS gel. Hence, these gels can be used to treat similar infectious conditions which are caused by bacteria and other microorganisms. Always consult the doctor before using any of these substitutes.

Can I drive or operate heavy machinery after taking this drug?

Yes, you can drive or operate heavy machinery after taking this drug. This drug does not have any capacity to affect the concentration or health of the patient. However, it is better to avoid driving or other activities if you feel dizziness or drowsiness along with any severe allergic reactions. Consult your doctor immediately in such cases.

What happens if I take the expired medicine?

This medicine, after getting expired, loses its efficiency to treat the specific condition. However, some may face the symptoms of allergic reactions such as swelling in face and lips, irritation and redness in the skin. So, it is safe to consult your physician as soon as possible if you have used the expired drug.

Can this drug be stopped abruptly?

No, this drug should not be stopped abruptly as it would result in the return of bacterial skin infections in the skin such as acne and pimples. But you may decrease the amount of deriva gel you are applying to the skin with the advice of your doctor. Even if the symptoms had disappeared or begin to fade, you should not stop the medication until you complete the dosage and the entire course of the treatment.

Are there any particular food items to be avoided while taking this drug?

It is always safe to avoid Vitamin A rich food items and the food items which can usually cause the allergic reactions in the person. Consult with your doctor for absolute clarity.

Can this Deriva gel be used for acne and pimples?

Yes, this Deriva gel can be used for acne and pimples. In fact, this gel is commonly prescribed as the primary medication in the treatment of Acne and pimples due to the presence of Adapalene and Clindamycin.

What are the benefits of the active ingredients present in this Deriva gel?

The two major active ingredients present in this Deriva gel have various benefits in treating the infections in the skin. Both ingredients have different ways to treat the conditions as explained below:

• Adapalene Microspheres: It is one of the forms of Vitamin A and it works by preventing the accumulation of the sebum (natural oil present in the skin which is secreted by the sebum gland). It is also involved in the process of unblocking the pores in the layer of the skin which in turn allows the natural exfoliation of the outer or external layers of the skin.
• Clindamycin Phosphate: It is considered one of the antibiotic substance. It is used for killing acne-causing bacteria or other infection-causing bacteria and skin breakout-causing microorganisms (other microscopic infectious organisms) by penetrating into the layer of the skin.

Reference

Wikipedia page on Epithelium

 

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